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Org Lett. 2004 Apr 29;6(9):1485-7.

Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O.

Author information

1
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. sajiki@gifu-pu.ac.jp

Abstract

[reaction: see text] An efficient and extensive deuterium incorporation using heterogeneous Pd/C-D(2)O-H(2) system into many different types of unactivated C-H bond positions was developed. The present method provides a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D(2)O media.

PMID:
15101773
DOI:
10.1021/ol0496374

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