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J Immunol. 2004 May 1;172(9):5287-96.

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.

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1
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Despite expression of the high-affinity IL-2R, CD4(+)CD25(+) regulatory T cells (Tregs) are hypoproliferative upon IL-2R stimulation in vitro. However the mechanisms by which CD4(+)CD25(+) T cells respond to IL-2 signals are undefined. In this report, we examine the cellular and molecular responses of CD4(+)CD25(+) Tregs to IL-2. IL-2R stimulation results in a G(1) cell cycle arrest, cellular enlargement and increased cellular survival of CD4(+)CD25(+) T cells. We find a distinct pattern of IL-2R signaling in which the Janus kinase/STAT pathway remains intact, whereas IL-2 does not activate downstream targets of phosphatidylinositol 3-kinase. Negative regulation of phosphatidylinositol 3-kinase signaling and IL-2-mediated proliferation of CD4(+)CD25(+) T cells is inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 10, PTEN.

PMID:
15100267
PMCID:
PMC2842445
DOI:
10.4049/jimmunol.172.9.5287
[Indexed for MEDLINE]
Free PMC Article

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