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Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):231-3.

[Preliminary study on proteomic patterns in hepatic tissue to identify HBV related hepatocellular carcinoma].

[Article in Chinese]

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  • 1Department of Infectious Diseases, XiangYa Hospital, Central South University, Changsha 410008, China.



To identify proteomic patterns in hepatic tissues for diagnosing early HBV related HCC.


Proteomic spectra were generated by two-dimensional gel electrophoresis (2-DE), A preliminary "raining" set of spectra derived from analysis of 14 cancer tissues and 14 non-cancer tissues, a proteomic patterns that completely discriminated cancer from non-cancer was identified. The discovered pattern was then used to classify an independent set of 48 masked samples: 24 from cancer tissues, and 24 from non-cancer tissues.


The discriminatory pattern correctly identified all cancer tissues and non-cancer tissues in the masked set. This result yielded a sensitivity of 100%, specificity of 100%.


Further analysis on these proteins in the proteomic pattern will be helpful to screen tumor markers for HBV related HCC. These findings justify a prospective assessment of proteomic pattern technology as a screening tool for cancer in high-risk and general populations.

[PubMed - indexed for MEDLINE]
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