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Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):231-3.

[Preliminary study on proteomic patterns in hepatic tissue to identify HBV related hepatocellular carcinoma].

[Article in Chinese]

Author information

  • 1Department of Infectious Diseases, XiangYa Hospital, Central South University, Changsha 410008, China.

Abstract

OBJECTIVE:

To identify proteomic patterns in hepatic tissues for diagnosing early HBV related HCC.

METHODS:

Proteomic spectra were generated by two-dimensional gel electrophoresis (2-DE), A preliminary "raining" set of spectra derived from analysis of 14 cancer tissues and 14 non-cancer tissues, a proteomic patterns that completely discriminated cancer from non-cancer was identified. The discovered pattern was then used to classify an independent set of 48 masked samples: 24 from cancer tissues, and 24 from non-cancer tissues.

RESULTS:

The discriminatory pattern correctly identified all cancer tissues and non-cancer tissues in the masked set. This result yielded a sensitivity of 100%, specificity of 100%.

CONCLUSION:

Further analysis on these proteins in the proteomic pattern will be helpful to screen tumor markers for HBV related HCC. These findings justify a prospective assessment of proteomic pattern technology as a screening tool for cancer in high-risk and general populations.

PMID:
15099477
[PubMed - indexed for MEDLINE]
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