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Nat Neurosci. 2004 May;7(5):493-4. Epub 2004 Apr 18.

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus.

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  • 1Department of Biological Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK.

Abstract

The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.

PMID:
15097991
DOI:
10.1038/nn1226
[PubMed - indexed for MEDLINE]
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