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Clin Appl Thromb Hemost. 2004 Apr;10(2):167-73.

Effect of ticlopidine on monocyte-derived microparticles and activated platelet markers in diabetes mellitus.

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Osaka Saiseikai Izuo Hospital based on Social Welfare Organization Saiseikai Imperial Gift Foundation Inc., Kitamura, Osaka, Japan.


Platelet-derived microparticles, activated platelets, and monocyte-derived microparticles were measured in 73 patients with diabetes mellitus. A comparative study of these parameters was performed before and after administration of ticlopidine. The number of platelet-derived microparticles and activated platelets was increased significantly in diabetic patients. Monocyte-derived microparticles were also increased significantly. After administration of ticlopidine, platelet-derived microparticles and activated platelets corrected positively, not only CD62P- and CD63-positive platelets, but also platelet-derived microparticles and monocyte-derived microparticles showed a significant decrease. These data suggest that in patients with diabetes, platelet-derived microparticles and activated platelets stimulate the activation of monocytes and promote the production of monocyte-derived microparticles, and that ticlopidine is useful for hypercoagulabillity in diabetic patients.

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