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FEBS Lett. 2004 Apr 23;564(1-2):153-6.

Disruption of type 5 adenylyl cyclase negates the developmental increase in Galphaolf expression in the striatum.

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Departments of Physiology and Medicine, Yokohama City University School of Medicine, Yokohama 234-0002, Japan.


The two stimulatory G protein alpha subunits, Galphas and Galphaolf, activate adenylyl cyclase in a similar way. We examined whether type 5 adenylyl cyclase knockout, the major striatal isoform, can differentially and/or developmentally change the expression of these G proteins in the striatum. Galphas and Galphaolf expressions at birth were unaffected in knockouts, which, however, demonstrated a blunted developmental increase in Galphaolf, but not Galphas. Adenylyl cyclase activity was unaffected at birth, but subsequently became lower in knockouts. These findings suggest that type 5 adenylyl cyclase does not contribute to striatal cAMP signaling at birth. However, it may play an important role in developmental changes in the expression of Galphaolf, but not Galphas.

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