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Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):146-51.

Feasibility of breast-conserving therapy for macroscopically multiple ipsilateral breast cancer.

Author information

1
Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Abstract

PURPOSE:

Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed.

METHODS AND MATERIALS:

Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease.

RESULTS:

After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was noted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion.

CONCLUSION:

Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique.

PMID:
15093910
DOI:
10.1016/j.ijrobp.2003.09.088
[Indexed for MEDLINE]

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