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Curr Opin Struct Biol. 2004 Apr;14(2):121-9.

RNA polymerase II structure, and organization of the preinitiation complex.

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1
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. asturias@scripps.edu

Abstract

Recent X-ray and cryo-electron microscopy studies have provided information about the basal eukaryotic transcription machinery and about Mediator, the complex involved in transcription regulation during initiation. On the basis of this structural information, a model describing the minimal transcription complex and its interaction with Mediator has been proposed. The model provides insight into the possible mechanisms of transcription initiation and regulation.

PMID:
15093825
DOI:
10.1016/j.sbi.2004.03.007
[Indexed for MEDLINE]
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