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Clin Neuropharmacol. 2004 Jan-Feb;27(1):30-2.

Dopaminergic hypersensitivity in patients with Parkinson disease and migraine.

Author information

1
Sanatorio del Rosario, Clinica de la Zarzuela, Department of Neurology, Madrid, Spain. ecubo@inicia.es

Abstract

Because migraine has been associated with dopaminergic receptor hypersensitivity, the authors hypothesized that patients with Parkinson disease with current or prior migraine have better dopaminergic response and less motor disability than Parkinson disease patients without migraine. Twenty-eight patients with Parkinson disease were included and matched (10 patients with migraine and 18 patients without migraine). Patients with Parkinson disease and migraine showed greater motor improvement during the ON state than patients without migraine with the same medication exposure. These data support the hypothesis that migraine may be associated with dopaminergic hypersensitivity.

PMID:
15090934
[Indexed for MEDLINE]
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