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Curr Opin Infect Dis. 2004 Feb;17(1):41-4.

Bacterial vaginosis and miscarriage.

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1
Department of Genitourinary Medicine, St George's Hospital Medical School, London, UK. phay@sghms.ac.uk

Abstract

PURPOSE OF REVIEW:

This review aims to summarize current knowledge about the relationship between bacterial vaginosis and miscarriage.

RECENT FINDINGS:

Studies investigating the relationship between bacterial vaginosis and infertility, implantation and early pregnancy loss have produced conflicting results. One study demonstrated a beneficial effect of colonization with hydrogen peroxide producing lactobacilli. A community based study found no association between bacterial vaginosis and first trimester loss, but a positive association with early second trimester loss. In a randomized controlled trial, treatment of bacterial vaginosis with oral clindamycin was associated with a fivefold reduction in the incidence of late miscarriage.

SUMMARY:

The relationship between bacterial vaginosis and infertility and first trimester loss needs further elucidation. Measures to support a healthy lactobacillus flora such as probiotic therapy warrant study. The randomized controlled trials of clindamycin treatment need to be replicated in different settings.

PMID:
15090889
[Indexed for MEDLINE]
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