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J Clin Invest. 2004 Apr;113(8):1084-92.

Antimalarial drug resistance.

Author information

1
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac

Abstract

Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. The de novo emergence of resistance can be prevented by the use of antimalarial drug combinations. Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective. Widespread use of these drugs could roll back malaria.

PMID:
15085184
PMCID:
PMC385418
DOI:
10.1172/JCI21682
[Indexed for MEDLINE]
Free PMC Article

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