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Ann Rheum Dis. 2004 May;63(5):588-90.

Steroids, non-steroidal anti-inflammatory drugs, and sigmoid diverticular abscess perforation in rheumatic conditions.

Author information

1
Academic Rheumatology Unit, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK. smpofu@liv.ac.uk

Abstract

BACKGROUND:

Corticosteroids and non-steroidal anti-inflammatory drugs are widely used for the treatment of rheumatic conditions, but their gastrointestinal damage significantly limits their use. Sigmoid diverticular abscess perforation (SDAP) is a very serious complication of diverticular disease.

OBJECTIVE:

To determine the aetiology of large bowel SDAP in rheumatic conditions.

METHODS:

64 patients with SPAD and 320 controls from a similar geographical area and of similar socioeconomic status were studied.

RESULTS:

The results showed that independently of rheumatic diagnosis corticosteroid treatment is strongly associated with SDAP (OR 31.9 (95% CI 6.4 to 159.2; p<0.001), and non-steroidal anti-inflammatory drugs only weakly associated (OR 1.8 (95% CI 0.96 to 3.4); p = 0.069). A rheumatic diagnosis is also strongly associated with the development of SDAP (OR 3.5 (95% CI 1.9 to 6.7); p<0.001).

CONCLUSIONS:

SDAP has serious implications for patients and consumes many healthcare resources. Patients and physicians should be warned of this potential complication.

PMID:
15082493
PMCID:
PMC1755003
DOI:
10.1136/ard.2003.010355
[Indexed for MEDLINE]
Free PMC Article

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