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Ann Rheum Dis. 2004 May;63(5):578-82.

Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression.

Author information

1
Department of Pathophysiology, Medical School, National University of Athens, Athens, Greece.

Abstract

BACKGROUND:

Patients with myelodysplasia may have autoimmune manifestations (AIM). Interferon regulatory factor-1 (IRF-1) is a transcription factor involved in interferon signalling, leukaemogenesis, and the development of the immune system.

OBJECTIVES:

To determine whether IRF-1 is implicated in the pathophysiology of AIM in myelodysplasia.

METHODS:

14 patients with myelodysplasia were studied, seven with AIM and seven without. Five patients with vasculitis and seven normal subjects served as controls. The expression of IRF-1 was studied in bone marrow mononuclear cells taken from patients and controls, using a relative quantitative reverse transcriptase polymerase chain reaction.

RESULTS:

A 10-fold reduction in full length IRF-1 mRNA was detected in the myelodysplasia patients without AIM compared with the normal controls. In contrast, the group with AIM had increased IRF-1 transcripts, to a level almost equal to that observed in patients with vasculitis and normal controls.

CONCLUSIONS:

Myelodysplasia patients without IRF-1 expression had a decreased incidence of AIM. Thus the absence of IRF-1 transcription factor appears to protect against the development of autoimmunity in myelodysplasia.

PMID:
15082491
PMCID:
PMC1754981
DOI:
10.1136/ard.2003.012948
[Indexed for MEDLINE]
Free PMC Article

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