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Neurosci Lett. 2004 Apr 29;360(3):161-4.

Nocturnal urinary dopamine excretion is reduced in otherwise healthy subjects with periodic leg movements in sleep.

Author information

1
Department of Psychiatry and Psychotherapy, Georg-August-University of Göttingen, von-Siebold Strasse 5, D-37075 Göttingen, Germany. scohrs@gwdg.de

Abstract

The pathophysiology of periodic leg movements (PLMs) in sleep remains to be elucidated. Among other hypotheses an alteration of dopaminergic function has been suggested. Nocturnal urinary dopamine and 4-hydroxy-3-methoxyphenylacetic acid excretion in otherwise healthy subjects with PLMs was significantly reduced (P < 0.001 and P < 0.05, respectively) compared to subjects without PLMs. This finding, for the first time, demonstrates a correlate of a functionally relevant hypoactivity of the dopaminergic system in subjects with PLMs.

PMID:
15082158
DOI:
10.1016/j.neulet.2004.02.056
[Indexed for MEDLINE]

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