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J Neuroimmunol. 2004 May;150(1-2):178-85.

HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe.

Author information

1
Dipartimento di Scienze Neurologiche e Psichiatriche, Univ. Firenze, Florence, Italy.

Abstract

The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c)<10(-6); Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; p(c)=0.047) and DRB1*07 decreased (OR=0.60; p(c)=1.3 x 10(-3)) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.

PMID:
15081263
DOI:
10.1016/j.jneuroim.2004.01.015
[Indexed for MEDLINE]

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