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Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50.

Biaryl amide glucagon receptor antagonists.

Author information

1
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. ravi.kurukulasuriya@abbott.com

Abstract

Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.

PMID:
15080976
DOI:
10.1016/j.bmcl.2004.02.056
[Indexed for MEDLINE]

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