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Nutr Rev. 2004 Feb;62(2):65-7.

Vitamin A supplementation and risk of skeletal fracture.

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Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo, Av Dr Arnaldo, 715, Cep 01246-904, São Paulo, Brazil.


Effects of toxic amounts of vitamin A include skeletal effects; from acute toxic exposure to chronic high-dose intake of vitamin A, these effects have led experts to speculate that long-term consumption of diets high in vitamin A (retinol) stimulates bone resorption and inhibits bone formation, and may contribute to osteoporosis and hip fractures.

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