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Scand J Rheumatol. 2003;32(6):343-7.

Long-term outcome of primary Raynaud's phenomenon and its conversion to connective tissue disease: a 12-year retrospective patient analysis.

Author information

1
Division of Angiology, Clinic for Internal Medicine II, University Hospital School of Medicine, Vienna, Austria. sophie.ziegler@akh-wien.ac.at

Abstract

OBJECTIVES:

To determine the frequency of development of connective tissue disease (CTD) in patients considered to have idiopathic Raynaud's phenomenon (RP) > 10 years.

PATIENTS AND METHODS:

Based on initial evaluation, 113 women and 29 men were divided into either 'primary RP' (n=109) or 'possible secondary RP' (n=33) groups and were re-evaluated after a median follow-up period of 12.4 years.

RESULTS:

Overall 20 patients (14.1%) progressed to a definite CTD; 10 from 'primary RP' (9.2%) and 10 from possible secondary RP' (30.3%). Initial presence of antinuclear antibodies, thickening of fingers, higher age at onset of RP, and female sex seemed to be important determinants for a possible transition to a CTD.

CONCLUSION:

In RP-patients, who are at risk of development of a CTD, serial clinical and laboratory controls are warranted for the decision to initiate therapy early.

PMID:
15080265
DOI:
10.1080/03009740410005007
[Indexed for MEDLINE]

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