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Neurology. 2004 Apr 13;62(7):1187-9.

Antiplatelet drug discontinuation is a risk factor for ischemic stroke.

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Fédération de neurosciences cliniques, CHU Bordeaux, France.


Antiplatelet drugs (APD) are widely used in the prevention of ischemic cardio- and cerebrovascular diseases. The authors studied the frequency of stroke occurring after APD discontinuation, the cause of discontinuation, and the delay between APD disruption and stroke. Only 4.49% of strokes were related to a recent APD discontinuation, but all cases occurred between 6 and 10 days after drug discontinuation (p < 0.0001). This temporal pattern has biologic plausibility because the inhibited platelets circulate in the blood for about 10 days.

[Indexed for MEDLINE]

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