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Emerg Infect Dis. 2004 Jan;10(1):69-75.

Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan.

Author information

1
Gifu Prefectural Office of Meat Inspection, Gifu, Japan. shiraki-yutaka@pref.gifu.lg.jp

Abstract

From November 2000 to June 2001, Escherichia coli strains producing CTX-M-2 beta-lactamase were isolated from 6 (1.5%) of 396 cattle fecal samples and 2 (0.7%) of 270 surface swabs of cattle carcasses in Japan. The blaCTX-M-2 gene responsible for CTX-M-2 production was encoded on transferable plasmids, and the gene was transferred to E. coli CSH2 with a very high frequency (2 x 10(-4) to 6 x 10(-1) per donor cells) by conjugation. Random amplified polymorphic DNA analysis of nine isolates showed at least five different patterns. These findings suggest that CTX-M-2 producers might have originated from cattle through the use of cephalosporins such as ceftiofur and that cattle could be a reservoir of CTX-M-2-producing E. coli. Continuous and strategic surveillance of antimicrobial-resistant bacteria in livestock is essential to suppress further dissemination of these bacteria into society at large.

PMID:
15078599
PMCID:
PMC3322752
DOI:
10.3201/eid1001.030219
[Indexed for MEDLINE]
Free PMC Article

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