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Sex Transm Dis. 2004 Mar;31(3):196-9.

Relapse of secondary syphilis after benzathine penicillin G: molecular analysis.

Author information

1
Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, Washington, USA.

Abstract

BACKGROUND AND OBJECTIVES:

It is difficult to distinguish between relapse and reinfection in patients who develop a second episode of syphilis after treatment.

GOAL:

The goal of this study was to use molecular methods to distinguish between relapse and reinfection in a patient with recurrent secondary syphilis.

STUDY DESIGN:

Treponema pallidum tprK sequences were amplified from cerebrospinal fluid (CSF), skin, and blood from the initial presentation and from blood from the second presentation. Neighbor-joining clustering analysis was performed for deduced tprK sequences from the case patient and for sequences derived from blood and CSF of a different patient with secondary syphilis.

RESULTS:

The case patient's tprK sequences from both episodes of syphilis clustered together with a high degree of similarity.

CONCLUSION:

Our patient likely relapsed despite treatment.

PMID:
15076935
[Indexed for MEDLINE]

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