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Neuroreport. 2004 Feb 9;15(2):321-4.

Tandem-pore K(+) channels display an uneven distribution in amphibian retina.

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1
CMBN, Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Box 60-327, Bayamón, Puerto Rico 00960-6032.

Abstract

Previous studies in retinal glial (Müller) cells have suggested that the dominant membrane currents are mediated by K(+) inward-rectifier (Kir) channels. After blockade of inwardly (Kir) and outwardly (KD and BK) conducting channels, a large K(+) conductance remains, but its nature has not been determined. Tandem-pore K(+) channels are likely candidates for this potassium conductance and the purpose of the present study was to determine, using immunocytochemistry, whether Müller cells express TASK-1, TASK-2, TREK-1 and/or TREK-2 potassium channel subunits. The results reveal that retinal glial cells express TASK-1 and TASK-2 subunits, but not TREK-1 or TREK-2 subunits. Furthermore, the distribution of TASK subunits differs from that of Kir channels and may contribute to the potassium conductance of Müller cells.

PMID:
15076761
[Indexed for MEDLINE]
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