Format

Send to

Choose Destination
AIDS. 2004 Jan 23;18(2):329-31.

Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library.

Author information

1
Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, USA.

Abstract

A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C, and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

PMID:
15075554
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center