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FEBS Lett. 2004 Mar 26;562(1-3):11-5.

Hsp90 isoforms: functions, expression and clinical importance.

Author information

1
Department of Medical Chemistry, Semmelweis University School of Medicine, Budapest, Hungary.

Abstract

The 90 kDa heat shock protein, Hsp90, is a main functional component of an important cytoplasmic chaperone complex, and it is involved in various cellular processes, such as cell proliferation, differentiation and apoptosis. Identification of Hsp90 as a molecular target of various anticancer drugs highlighted its importance from the clinical point of view. Here we summarize the current knowledge of various Hsp90 isoforms regarding their genomic location, molecular evolution, functional differences, differential induction after various environmental stresses and in pathological conditions as well as the growing importance of discriminating between Hsp90 isoforms in clinical practice.

PMID:
15069952
DOI:
10.1016/s0014-5793(04)00229-7
[Indexed for MEDLINE]
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