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J Pediatr. 2004 Apr;144(4):524-6.

Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses.

Author information

1
Division of Allergy and Immunology, Department of Pediatrics, University of South Florida All Children's Hospital, Box 7070, 801 6th Street South, St Petersburg, FL 33701, USA. dayn@allkids.org

Abstract

We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficiency.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.

PMID:
15069404
DOI:
10.1016/j.jpeds.2003.11.025
[Indexed for MEDLINE]

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