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Virus Res. 2004 Jun 1;102(1):59-64.

RNA interference against retroviruses.

Author information

1
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA.

Abstract

Bang and Ellerman, and later Peyton Rous, reported the first identification of transmissible cancer-causing agents, which later turned out to be avian retroviruses. Today avian retroviruses are important models for study of retrovirus replication and pathogenesis, and also important pathogens of domestic fowl. Here we describe the use of RNA interference (RNAi) in live chick embryos to block replication of an avian retrovirus. We also describe inhibition of ASLV and HIV replication in cell culture with RNAi.

PMID:
15068881
DOI:
10.1016/j.virusres.2004.01.016
[Indexed for MEDLINE]

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