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Australas J Dermatol. 2004 May;45(2):140-3.

Intralesional 5-fluorouracil in the treatment of keloid scars.

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1
Specialist Cosmetic Laser Clinic, 8th Floor, Trak Centre, 445 Toorak Road, Toorak 5142, Melbourne, Victoria, Australia. greggoodman@greggoodman.com.au

Abstract

Two patients with keloid scars are described. The first patient presented with extensive keloid scarring on both cheeks secondary to acne. The second patient developed a keloid scar on her chest following excision of a mole. Both patients' scars were diagnosed clinically and treated with fortnightly injections of a mixture of 5-fluorouracil and betamethasone acetate and betamethasone sodium phosphate. At each injection session up to 1.6 mL of 5-fluorouracil at a concentration of 500 mg/10 mL and 0.4 mL of betamethasone acetate and betamethasone sodium phosphate (as betamethasone acetate 3 mg in suspension and betamethasone sodium phosphate 3.9 mg in solution) were used. Multiple treatments were required to obtain resolution of the keloid scars. Improvement was maintained in both patients at 1 year post treatment.

[Indexed for MEDLINE]

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