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J Clin Invest. 2004 Mar;113(6):808-10.

The immune response to AIDS virus infection: good, bad, or both?

Author information

1
Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Abstract

A potent antigen-specific T cell response to HIV infection can contribute to the control of viral replication and is therefore beneficial to the host. However, HIV-mediated increases in generalized T cell activation also appear to accelerate both viral replication and CD4+ T cell depletion. A new study in the JCI attempts to experimentally distinguish the beneficial versus harmful aspects of this immune response.

PMID:
15067312
PMCID:
PMC362127
DOI:
10.1172/JCI21318
[Indexed for MEDLINE]
Free PMC Article

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