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Cell. 2004 Apr 2;117(1):9-15.

Early decision; meiotic crossover interference prior to stable strand exchange and synapsis.

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Department of Radiation & Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.


During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference.

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