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Curr Opin Chem Biol. 2004 Apr;8(2):120-6.

Recent advances in the biocatalytic reduction of ketones and oxidation of sec-alcohols.

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  • 1Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria.

Abstract

To improve the efficiency and applicability of biocatalytic redox-reactions for asymmetric ketone-reduction and enantioselective alcohol-oxidation catalyzed by nicotinamide-dependent dehydrogenases/reductases, several achievements for cofactor-recycling have been made during the last two years. First, the use of hydrogenases for NADPH recycling in a two enzyme system. Second, preparative transformations with alcohol dehydrogenases coupled with NADH oxidases for NAD+/NADP+ recycling. Third, an exceptional chemo-stable alcohol dehydrogenase can efficiently use i-propanol and acetone as cosubstrates for reduction and oxidation, respectively, in a single-enzyme system. Novel carbonyl reductases and dehydrogenases derived from plant cells are particularly suited for sterically demanding substrates.

PMID:
15062771
DOI:
10.1016/j.cbpa.2004.02.005
[PubMed - indexed for MEDLINE]
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