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Curr Biol. 2004 Apr 6;14(7):R284-6.

Genomic imprinting: CTCF protects the boundaries.

Author information

1
Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK.

Abstract

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

PMID:
15062124
DOI:
10.1016/j.cub.2004.03.026
[Indexed for MEDLINE]
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