Format

Send to

Choose Destination
Curr Biol. 2004 Apr 6;14(7):R277-8.

Signal transduction: implications for Ras-dependent ERK signaling.

Author information

1
Laboratory of Protein Dynamics and Signaling, NCI-Frederick, Frederick, Maryland 21702, USA.

Abstract

Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

PMID:
15062121
DOI:
10.1016/j.cub.2004.03.023
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center