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EMBO Rep. 2004 Apr;5(4):351-5.

Protein kinase CK2: a new view of an old molecular complex.

Author information

1
INSERM EMI 104, Département Réponse et Dynamique Cellulaire, CEA, 38054 Grenoble, France.

Abstract

Protein kinase CK2 (formerly known as casein kinase II) has been viewed traditionally as a stable heterotetrameric complex, but new analytical techniques are bringing a different picture into focus. The transient nature of this complex has been highlighted by the elucidation of its structure. Furthermore, analysis of the spatiotemporal organization of individual CK2 subunits in living cells has shown that they are dynamic and that they integrate into different multimolecular assemblies. These new studies give an additional dimension to the challenge of determining the cellular regulation of this protein kinase.

PMID:
15060571
PMCID:
PMC1299026
DOI:
10.1038/sj.embor.7400115
[Indexed for MEDLINE]
Free PMC Article

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