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FEMS Microbiol Lett. 1992 Jun 1;72(2):109-13.

High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus.

Author information

1
Department of Microbiology, Tokyo College of Pharmacy, Japan.

Abstract

A gene encoding high-level resistance to ethidium bromide (EB) and antiseptics was isolated from a transferable plasmid, pTZ22, in Staphylococcus aureus. DNA sequencing revealed that the plasmid has two copies of the ebr gene that normally mediates low-level resistance to EB and antiseptics. The efflux rate for EB of strains with duplicated ebr genes was twice the rate of strains with a single ebr gene. It was concluded that the duplication of ebr is responsible for the high-level resistance to EB and antiseptics.

PMID:
1505735
DOI:
10.1016/0378-1097(92)90514-o
[Indexed for MEDLINE]

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