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Mem Inst Oswaldo Cruz. 2004 Feb;99(1):1-12. Epub 2004 Mar 31.

Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease.

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1
Departamento de BioquĂ­mica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30161-970, Brasil.

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.

PMID:
15057339
[Indexed for MEDLINE]
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