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Nucleic Acids Res. 2004 Mar 31;32(6):1993-9. Print 2004.

ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae.

Author information

1
Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada.

Abstract

We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core component of the SSU processome. These data indicate that Esf1p plays a direct role in early pre-rRNA processing.

PMID:
15056729
PMCID:
PMC390369
DOI:
10.1093/nar/gkh518
[Indexed for MEDLINE]
Free PMC Article

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