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Eur J Clin Nutr. 2004 Sep;58(9):1319-22.

The genetic variant of lactase persistence C (-13910) T as a risk factor for type I and II diabetes in the Finnish population.

Author information

1
Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

Abstract

OBJECTIVE:

Lactase persistence (LP), the ability to maintain a high lactase activity throughout life, has been suggested to be a possible risk factor for diabetes. Recently, a single nucleotide polymorphism C (-13910) T, residing 14 kb from the 5' end of the lactase (LCT) gene was shown to be associated with LP. Here we have studied the relationship between C (13910) T polymorphism and diabetes in the Finnish population.

PATIENTS AND DESIGN:

In all, 1455 patients with type I and 615 with type II diabetes and 446 nondiabetic controls in the Finnish population were genotyped for the C (-13910) T polymorphism by PCR minisequencing.

RESULTS:

No differences were detected in the LP genotype frequencies (CT&TT) between diabetic and nondiabetic subjects.

CONCLUSIONS:

We conclude that the C (-13910) T polymorphism associated with lifelong LP is not a risk factor for type I or type II diabetes in the Finnish population.

PMID:
15054412
DOI:
10.1038/sj.ejcn.1601971
[Indexed for MEDLINE]

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