Format

Send to

Choose Destination
See comment in PubMed Commons below
Learn Mem. 2004 Mar-Apr;11(2):162-71.

Human central auditory plasticity associated with tone sequence learning.

Author information

1
Institute of Pharmacology and Toxicology and Institute of Child and Adolescent Psychiatry, University of Zürich, CH-8057 Zürich, Switzerland. jmgottselig@pharma.unizh.ch

Abstract

We investigated learning-related changes in amplitude, scalp topography, and source localization of the mismatch negativity (MMN), a neurophysiological response correlated with auditory discrimination ability. Participants (n = 32) underwent two EEG recordings while they watched silent films and ignored auditory stimuli. Stimuli were a standard (probability = 85%) and two deviant (probability = 7.5% each for high [HD] and low [LD]) eight-tone sequences that differed in the frequency of one tone. Between recordings, subjects practiced discriminating the HD or LD from the standard for 6 min. The amplitude of the LD MMN increased significantly across recordings in both groups, whereas the amplitude of the HD MMN did not. The LD was easier to discriminate than was the HD. Thus, practicing either discrimination increased the MMN for the easier discrimination. Learning and changes in the LD MMN amplitude were highly correlated. Source localizations of event-related potentials (ERPs) to all stimuli revealed bilateral sources in superior temporal regions. Compared with the standard ERP, the LD ERP revealed a stronger source in the left superior temporal region in both recordings, whereas the right-sided source became stronger after learning. Consistent with prior studies of auditory plasticity in animals and humans, tone sequence learning induced rapid neurophysiological plasticity in the human central auditory system. The results also suggest that there is asymmetric hemispheric involvement in tone sequence discrimination learning and that discrimination difficulty influences the time course of learning-related neurophysiological changes.

PMID:
15054131
PMCID:
PMC379686
DOI:
10.1101/lm.63304
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center