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Gene Expr Patterns. 2004 May;4(3):263-6.

The novel medaka transglutaminase gene is expressed in developing yolk veins.

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  • 1Department of Biological Information, Tokyo Institute of Technology, 4259, Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.


The vascular system is highly conserved in all vertebrates in the aspects of anatomy as well as in the genetic mechanism governing it. The embryo of the medaka, Oryzias latipes is small and transparent, providing many advantages for the experimental analysis of the vertebrate vascular system. We isolated a novel medaka transglutaminase gene, termed embryonic transglutaminase, and found that it showed the highest homology to the coagulation factor XIII A subunit of mammals. This gene is expressed in the anterior lateral plate mesoderm, and then expressed specifically in yolk veins consisting two ducts of Cuvier and the vitellocaudal vein. Our data is the first finding that a coagulation factor XIII-like gene is expressed in the early vascular development of vertebrates.

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