Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2004 Apr 1;1691(1):67-72.

Overexpression of receptor of advanced glycation end products hypersensitizes cells for amyloid beta peptide-induced cell death.

Author information

  • 1Institut für Neurobiochemie Universität Witten/Herdecke, Stockumer Str. 10, D-58448 Witten, Germany.

Abstract

Receptor of advanced glycation end products (RAGE) was identified as one of the receptors for amyloid beta peptide (Abeta). There is evidence for controversial functions of RAGE such as a mediator of cell death or differentiation. In this report, we demonstrate that RAGE mediates Abeta toxicity. Transient transfection of RAGE already induced cell death. For further analysis, stable clones of hemagglutinin (HA)-tagged RAGE were selected. Analysis of cellular localization of HA-tagged RAGE protein revealed, in addition to the expected cell surface expression, a novel intracellular localization. Stable RAGE-expressing cells were hypersensitive to nanomolar amounts of Abeta. Only cells expressing RAGE at the cell surface showed hypersensitivity to Abeta.

PMID:
15053925
DOI:
10.1016/j.bbamcr.2004.01.003
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center