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World J Gastroenterol. 2004 Apr 1;10(7):991-4.

Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.

Author information

1
Department of Internal Medicine, Cathay General Hospital, 280 Jen-Ai Road, Section 4, Taipei 106, Taiwan, China. yungchihlai@hotmail.com

Abstract

AIM:

To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers.

METHODS:

One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori density was histologically graded according to the Sydney system. Each patient received lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) for 1 week. According to pre-treatment UBT values, patients were allocated into low (<16 per thousand), intermediate (16-35 per thousand), and high (>35 per thousand) UBT groups.

RESULTS:

A significant correlation was found between pre-treatment UBT results and H pylori density (P<0.001). H pylori eradication rates were 94.9%, 94.4% and 81.6% in the low, intermediate and high UBT groups, respectively (per protocol analysis, P=0.11). When patients were assigned into two groups (UBT results < or =35 per thousand and >35 per thousand), the eradication rates were 94.7% and 81.6%, respectively (P=0.04).

CONCLUSION:

The intragastric bacterial load of H pylori can be evaluated by UBT, and high pre-treatment UBT results can predict an adverse outcome of eradication therapy.

PMID:
15052680
PMCID:
PMC4717118
DOI:
10.3748/wjg.v10.i7.991
[Indexed for MEDLINE]
Free PMC Article

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