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Biochem Cell Biol. 2004 Feb;82(1):129-44.

Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease.

Author information

1
Centro FONDAP de Estudios Molecualrs de la Célula, Programa de Biología Celular y Molecular, Universidad de Chile, Indepencia 1027, Santiago, Chile. aquest@med.uchile.cl

Abstract

Caveolae were initially described some 50 years ago. For many decades, they remained predominantly of interest to structural biologists. The identification of a molecular marker for these domains, caveolin, combined with the possibility to isolate such cholesterol- and sphingolipid-rich regions as detergent-insoluble membrane complexes paved the way to more rigorous characterization of composition, regulation, and function. Experiments with knock-out mice for the caveolin genes clearly demonstrate the importance of caveolin-1 and -3 in formation of caveolae. Nonetheless, detergent-insoluble domains are also found in cells lacking caveolin expression and are referred to here as lipid rafts. Caveolae and lipid rafts were shown to represent membrane compartments enriched in a large number of signaling molecules whose structural integrity is essential for many signaling processes. Caveolin-1 is an essential structural component of cell surface caveolae, important for regulating trafficking and mobility of these vesicles. In addition, caveolin-1 is found at many other intracellular locations. Variations in subcellular localization are paralleled by a plethora of ascribed functions for this protein. Here, more recent data addressing the role of caveolin-1 in cellular signaling and the development of diseases like cancer will be preferentially discussed.

PMID:
15052333
DOI:
10.1139/o03-071
[Indexed for MEDLINE]

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