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Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5048-52. Epub 2004 Mar 29.

Tyrosol is a quorum-sensing molecule in Candida albicans.

Author information

1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

Abstract

The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process must be under complex positive and negative control by environmental conditions. The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.

PMID:
15051880
PMCID:
PMC387371
DOI:
10.1073/pnas.0401416101
[Indexed for MEDLINE]
Free PMC Article

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