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Cell. 1992 Aug 21;70(4):609-20.

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.

Author information

1
Howard Hughes Medical Institute, University of California, Berkeley 94720.

Abstract

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

PMID:
1505027
DOI:
10.1016/0092-8674(92)90430-k
[Indexed for MEDLINE]

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