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J Pept Res. 2004 Mar;63(3):207-12.

The coactivator LXXLL nuclear receptor recognition motif.

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1
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.

Abstract

Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.

[Indexed for MEDLINE]

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