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J Neurosci Res. 2004 Apr 1;76(1):129-40.

Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants.

Author information

1
Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA. buenafea@ohsu.edu

Abstract

Although the phenotypic and regulatory properties of the CD4(+)CD25(+) T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4(+)CD25(+) Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoire as well as that of a clonotypic nongermline-encoded CDR3beta sequence present in a recombinant soluble T cell receptor (TCR) protein. Regulatory activity was demonstrated in T cell lines responsive to TCR but not in T cell lines responsive to control antigens. Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants.

PMID:
15048937
DOI:
10.1002/jnr.20066
[Indexed for MEDLINE]

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