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Nat Neurosci. 2004 Apr;7(4):327-32.

Neural activity and the dynamics of central nervous system development.

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1
Department of Molecular and Cellular Physiology, Beckman Center B141, Stanford University, Stanford, California 94305, USA.

Abstract

Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural activity modulates development through biasing this process of formation and elimination, promoting the formation and stabilization of appropriate synaptic connections on the basis of functional activity patterns.

PMID:
15048120
DOI:
10.1038/nn1218
[Indexed for MEDLINE]
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