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J Virol. 2004 Apr;78(8):3846-50.

Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.

Author information

1
Institute of Virology, University of Zurich, Zurich, Switzerland.

Abstract

The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.

PMID:
15047800
PMCID:
PMC374284
DOI:
10.1128/jvi.78.8.3846-3850.2004
[Indexed for MEDLINE]
Free PMC Article

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