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Trends Neurosci. 2004 Apr;27(4):186-93.

Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons.

Author information

1
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA.

Abstract

The performance of the brain is constrained by wiring length and maintenance costs. The apparently inverse relationship between number of neurons in the various interneuron classes and the spatial extent of their axon trees suggests a mathematically definable organization, reminiscent of 'small-world' or scale-free networks observed in other complex systems. The wiring-economy-based classification of cortical inhibitory interneurons is supported by the distinct physiological patterns of class members in the intact brain. The complex wiring of diverse interneuron classes could represent an economic solution for supporting global synchrony and oscillations at multiple timescales with minimum axon length.

PMID:
15046877
DOI:
10.1016/j.tins.2004.02.007
[Indexed for MEDLINE]

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