Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2004 Feb;4(2):123-32.

The many important facets of T-cell repertoire diversity.

Author information

  • 1Vaccine and Gene Therapy Institute, Department of Molecular Microbiology and Immunology and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA. nikolich@ohsu.edu

Abstract

In the thymus, a diverse and polymorphic T-cell repertoire is generated by random recombination of discrete T-cell receptor (TCR)-alphabeta gene segments. This repertoire is then shaped by intrathymic selection events to generate a peripheral T-cell pool of self-MHC restricted, non-autoaggressive T cells. It has long been postulated that some optimal level of TCR diversity allows efficient protection against pathogens. This article focuses on several recent advances that address the required diversity for the generation of an optimal immune response.

PMID:
15040585
DOI:
10.1038/nri1292
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center